Skin and soft tissue infections sstis account for more than 14 million physician office visits each year in the united states as well as emergency department visits and hospitalizations1 the . A skin injury or wound can be open closed or torn wounds that are open run the risk of infections and closed wounds can lead to tissue damage a soft tissue injury sti can occur from a sprain strain contusion or overuse of a particular body area where muscles ligaments and tendons have become damaged. Skin and soft tissue infections sstis are clinical entities of variable presentation etiology and severity that involve microbial invasion of the layers of the skin and underlying soft tissues sstis range from mild infections such as pyoderma to serious life threatening infections such as necrotizing fasciitis. Skin and soft tissues are common sites of infection for hiv negative patients with a compromised immune system posing a major diagnostic challenge 178 179 as the differential diagnosis is broad and includes drug eruption skin or soft tissue infiltration with the underlying malignancy chemotherapy or radiation induced skin reactions
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