The 1980s and 1990s have witnessed a worldwide epidemic of heroin addiction and countries around the world have moved to put in place opiate replacement therapy programs to deal with this problem while most of these programs use methadone as a substitute drug of choice most recently buprenorphine laam levo acetyl methadol and heroin have been employed for this purposea comprehensive . Abstract background methadone maintenance was the first widely used opioid replacement therapy to treat heroin dependence and it remains the best researched treatment for this problem despite the widespread use of methadone in maintenance treatment for opioid dependence in many countries it is a controversial treatment whose effectiveness has been disputed. Opiate replacement therapy is a treatment option for opioid addiction that has existed since the early 1970s doctors and researchers have improved the program over time and while two types of opiate replacement therapy medications now exist for the treatment of this addiction syndrome every patient is different in their requirements for care and should be considered for their specific needs . Methadone is a full opioid agonist with a long half life generally remaining effective for 2 36 hours this medication has been used for many years for opioid replacement therapy because it does not have the same intoxicating effect as other short acting opioids methadone can be dispensed at federally regulated clinics. Methadone maintenance treatment mmt a form of opioid replacement therapy reduces and or eliminates the use of illegal opiates the criminality associated with opiate use and allows patients to improve their health and social productivity methadone is an agonist of opioids
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