Cardiovascular diseases genetics epidemiology and prevention oxford monographs on medical genetics james j nora kare berg audrey hart nora on amazoncom free shipping on qualifying offers knowledge of what causes cardiovascular diseases has progressed at a pace that challenges not only the student. The perception of genetic diseases of the heart and vascular system has dramatically changed over the last 10 years next generation sequencing and arrays with millions of single nucleotide polymorphisms allowed significant advances in the understanding of monogenic and polygenic diseases the chapters in genetics of cardiovascular diseases written by outstanding experts in the field . Cardiovascular disease cvd which represents a major health problem around the world and involves the heart brain and peripheral circulation is a complex genetic trait with multiple genetic and environmental components contributing to the observed phenotype. Introduction the pathology of and the genetic architecture of coronary heart disease coronary heart disease chd has both genetic and environmental precipitants and is a leading cause of morbidity and mortality globally 1 the major risk factors for the development of chd are male gender increasing age elevated levels of plasma low density . Genetic epidemiology uses unique case control family and population based designs and genotyping from multiple sources our goal has been to learn about genetic susceptibility to disease and genetic determinants of therapeutic responsiveness a full series in genetic epidemiology is offered in the johns hopkins bloomberg school of public health
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