A diagnosis of bisphosphonate associated osteonecrosis of the jaw relies on three criteria the patient possesses an area of exposed bone in the jaw persisting for more than 8 weeks the patient must present with no history of radiation therapy to the head and neck the patient must be taking or have taken bisphosphonate medication. Bisphosphonates pyrophosphate analogs which potently inhibit osteoclastic bone resorption are now firmly established as first line therapy for osteoporosis several bisphosphonates of varying antiresorptive potency are either in clinical use or well advanced in clinical trials alendronate and . Bisphosphonate on bones 1e 1st edition by h a fleisch editor r e canfield editor olm bijvoet editor need it fast 2 day shipping options during the last quarter of a century bisphosphonates have become a major tool in the management of . Bisphosphonate and cancer cancer patients mostly those with multiple myeloma and breast cancer whose disease has spread to their bones generally take one of two bisphosphonates zometa or the older aredia intravenously use after breast cancer bisphosphonates inhibit the growth of breast cancer bone metastases in a mouse model previous
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